“Thymoquinone modulates nine of the ten hallmarks of cancer.”
There are very many research studies that show great results for black seed oil treatments related to its’ cancer killing and anti-inflammatory properties.
What is Cancer?
Well, of course, that depends on what type of cancer that we are talking about. In it’s most basic explanation, cancer is cells gone wrong. The cause of which is most often not discovered. There are benign cancers and malignant cancers. It’s the latter you have to worry about.
The Research
There have been many studies that have shown the effects of Nigella sativa on many different cancers and I will quote just a few of them here. The full list of research studies that I found is included at the end of this chapter. The list is long!
Even doctors are now urging more research into thymoquinone (TQ) the main constituent in black seed oil, for adjuvants to pharmaceutical cancer treatments – REF – ‘Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment: Evidence from Preclinical Studies.’
What the scientists are looking to discover are the exact signalling pathways that helps black cumin seed oil play such a big role in killing cancer.
Many Pathways To Healing
“The anti-cancer effects of thymoquinone are mediated through different modes of action, including anti-proliferation, apoptosis induction, cell cycle arrest, ROS generation and anti-metastasis/anti-angiogenesis. In addition, this quinone was found to exhibit anti-cancer activity through the modulation of multiple molecular targets, including p53, p73, PTEN, STAT3, PPAR-?, activation of caspases and generation of ROS.
Thymoquinone is an active ingredient isolated from Nigella sativa and has been investigated for its anti-oxidant, anti-inflammatory and anti-cancer activities in both in vitro and in vivo models since its first extraction in 1960s.
Its anti-oxidant/anti-inflammatory effect has been reported in various disease models, including encephalomyelitis, diabetes, asthma and carcinogenesis.
In addition, thymoquinone could act as a free radical and superoxide radical scavenger, as well as preserving the activity of various anti-oxidant enzymes such as catalase, glutathione peroxidase and glutathione-S-transferase.”
More Amazing Cancer Research With Black Seed Oil
“As non-invasive lesions progress to malignancy, the precursor period provides a window for cancer therapies that can interfere with neoplastic progression. Thymoquinone (Tq), a major bioactive component of essential oil from Nigella sativa’s seeds, has demonstrated antineoplastic activities in multiple cancers” REF – ‘Molecular Analysis of Precursor Lesions in Familial Pancreatic Cancer’
“A cell study conducted at the International Immuno – Biology Research Laboratory in South Carolina showed that when incubated with Nigella extract, cancer cells were unable to produce fibroblast growth factor and the protein collagenase, both are necessary for blood-vessel growth into a tumour. Without a blood supply, a tumour cannot grow”
“Thymoquinone blocked angiogenesis in vitro and in vivo, prevented tumour angiogenesis in a xenograft human prostate cancer (PC3) model in mouse, and inhibited human prostate tumour growth at low dosage with almost no chemotoxic side effects. Overall, our results indicate that thymoquinone inhibits tumour angiogenesis and tumour growth and could be used as a potential drug candidate for cancer therapy.”
“In fact, thymoquinone suppresses growth and invasion, and induces apoptosis of glial tumour cells via degrading tubulins and inhibiting 20S proteasome, telomerase, autophagy, FAK and metalloproteinases. A simple and easily available agent may be a promising adjunctive treatment option in neurological and neurosurgical practice.”
“TQ was found to increase sub-G1 accumulation and annexin-V positive staining, indicating apoptotic induction.”
“Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein.”
In the International Journal of Oncology we find a study that tells us, “Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism.” They also had this to say, “These results indicate that TQ is antineoplastic and pro-apoptotic against colon cancer cell line HCT116. The apoptotic effects of TQ are modulated by Bcl-2 protein and are linked to and dependent on p53. Our data support the potential for using the agent TQ for the treatment of colon cancer.”
From the same study; “Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism.”
Still from the same study, “These results indicate that TQ is antineoplastic and pro-apoptotic against colon cancer cell line HCT116. The apoptotic effects of TQ are modulated by Bcl-2 protein and are linked to and dependent on p53. Our data support the potential for using the agent TQ for the treatment of colon cancer.” Meaning the black seed oil is killing cancer cells! REF – ‘Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism’
From a 2003 study we find, “Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells.” More cancer cell killing evidence.
From another study in 2003 the good news for epilepsy sufferers is, “These findings demonstrate that the volatile oil of N. sativa has the ability to inhibit colon carcinogenesis of rats in the postinitiation stage, with no evident adverse side effects, and that the inhibition may be associated, in part, with suppression of cell proliferation in the colonic mucosa”
The very best research on the effect of black cumin on cancers was conducted via a review of research papers in 2011. In this study the role of black cumin as an anti-cancer agent is explained thus, “Many active ingredients have been found in the seeds of N. sativa. The seeds contain both fixed and essential oils, proteins, alkaloids and saponin described the quantification of four pharmacologically important components: thymoquinone (TQ), dithymoquinone (DTQ), thymohydroquinone (THQ), and thymol (THY), in the oil of N. sativa seed by HPLC. Much of the biological activities of the seeds have been shown to be due to thymoquinone, the major component of the essential oil, which is also present in the fixed oil”
In a review study the researchers have offered up 57 reviewed research papers on this subject and found black cumin to be effective against these cancers;
– Blood cancer – El-Mahdy et al. (2005), Effenberger et al. (2010), Swamy and Huat (2003)
– Breast cancer – Farah and Begum (2003), (El-Aziz et al., 2005), Effenberger et al. (2010)
– Colon cancer – Gali-Muhtasib et al. (2004), Salim and Fukushima (2003), Norwood et al. (2006)
– Pancreatic cancer – Chehl et al. (2009), Banerjee et al., (2009), Torres et al. (2010)
– Hepatic cancer – Thabrew et al. (2005), Nagi and Almakki (2009)
– Lung cancer – Swamy and Huat (2003), Mabrouk et al. (2002)
– Leukemia – El-Mahdy et al. (2005)
– Skin cancer – Salomi et al. (1991)
– Fibrosarcoma – Badary and Gamal (2001)
– Renal cancer – Khan and Sultana (2005)
– Prostate cancer – Kaseb et al. (2007), Yi et al. (2008)
– Cervical cancer – Shafi et al. (2009), Effenberger et al. (2010)
Already Getting Chemotherapy?
You might want to have a look at the study from 2010 that tested the effectiveness of protection afforded by black cumin against the toxicity of the drug cyclophosphamide. The researchers stated, “These results suggest that administration of NSO or TQ can lower CTX-induced toxicity as shown by an up-regulation of antioxidant mechanisms, indicating a potential clinical application for these agents to minimise the toxic effects of treatment with anticancer drugs”
Protection Against Radiotherapy
In 2009 in a study of 60 rats, it was found that, “Our results strongly recommend Nigella sativa oil as a promising natural radioprotective agent against immunosuppressive and oxidative effects of ionizing radiation.”
As you can see, there is a LOT of potential healing to be had with the little black cumin seed, even on cancers. There is so much research available that it begs the question, “Why aren’t cancer patients routinely treated with black cumin seed oil?”
References
‘Modulation of apoptosis in human hepatocellular carcinoma (HepG2 cells) by a standardized herbal decoction of Nigella sativa seeds, Hemidesmus indicus roots and Smilax glabra rhizomes with anti- hepatocarcinogenic effects.’ https://www.ncbi.nlm.nih.gov/pubmed/22458551 (as accessed 31 Jan 2018).
‘Protective effects of Nigella sativa oil and thymoquinone against toxicity induced by the anticancer drug cyclophosphamide’ https://www.ncbi.nlm.nih.gov/pubmed/20373678 (as accessed 31 Jan 2018).
‘Anticancer Activities of Nigella Sativa (Black Cumin)’ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252704/ (as accessed 31 Jan 2018).
‘Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment: Evidence from Preclinical Studies’ https://www.ncbi.nlm.nih.gov/pubmed/28659794 (as accessed 4 Feb 2018).
‘Thymoquinone: fifty years of success in the battle against cancer models’ https://www.sciencedirect.com/science/article/pii/S1359644613002882 (as accessed 31 Jan 2018).
‘Molecular Analysis of Precursor Lesions in Familial Pancreatic Cancer’ https://www.researchgate.net/publication/235393451 (as accessed 4 Feb 2018).
‘Hormonal Contents of Two Types of Black Seed (Nigella sativa) Oil: Comparative Study’ https://www.iasj.net/iasj?func=fulltext&aId=42676 (as accessed 4 Feb 2018).
‘Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways’ https://www.ncbi.nlm.nih.gov/pubmed/18644991 (as accessed 4 Feb 2018).
‘Thymoquinone: An edible redox-active quinone for the pharmacotherapy of neurodegenerative conditions and glial brain tumors. A short review’
https://www.sciencedirect.com/science/article/pii/S0753332216307302 (as accessed 4 Feb 2018).
‘Anticancer activity of thymoquinone in breast cancer cells: Possible involvement of PPAR-? pathway’ https://www.sciencedirect.com/science/article/pii/S0006295211003637 (as accessed 4 Feb 2018).
Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein’ https://www.sciencedirect.com/science/article/pii/S0887233311001366 (as accessed 4 Feb 2018).
‘Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism’ https://www.researchgate.net/publication/8338395 (as accessed 4 Feb 2018).
Thymoquinone Inhibits Autophagy and Induces Cathepsin-Mediated, Caspase-Independent Cell Death in Glioblastoma Cells’ http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072882 (as accessed 4 Feb 2018).
‘Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis’
http://www.tandfonline.com/doi/abs/10.1207/S15327914NC4502_09 (as accessed 4 Feb 2018).
‘Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats’ http://www.tandfonline.com/doi/full/10.3109/08923970903307552 (as accessed 4 Feb 2018).
Come with me on a journey of scientific research and thousands of years of human healing with the amazing black seed oil. Call it what you like… Barakat, Black coriander, Black cumin, Black seed, Charnuska, Cheveux de Vénus, Cominho Negro, Cumin Noir, Fennel flower, Fitch, Graine de Nigelle, Graine Noire, Habbatus sauda, Kalajaji, Kalajira, Kalonji, La Grainer Noire, Love in a Mist, Mugrela, Nielle, Nigella sativa, Nigelle Cultivée, Nigelle de Crête, Nutmeg Flower, Poivrette, Roman-Coriander, Schwarzkummel, Small Fennel, Toute Épice, Upakuncika. Get in the loop for the free book giveaway on publishing day here… https://www.detoxnaturalliving.com/blackseedoilmasterguide.html
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