The Danger of Chitin Synthesis Inhibitors

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The range of candida treatments ranges from time-proven and safe fatty acids, to dangerous drugs that create resistant strains, to obscure treatments like turpentine. With candida being an orphaned condition by the medical profession, many people take advantage of this by selling anything and everything. While promising a quick cure, they put down everyone else and load their marketing materials with fear and emotional messages in an attempt to steer people away from following sound advise. Chitin Synthesis Inhibitors, also known as Lufenuron, are a good example of this trend. Designed and marketed as a flea medication for pets, at least two sites are trying to market it as a treatment for candida, in spite of the science that shows it doesn’t work against fungus.

Lufenuron is being pitched to candida sufferers as an effective anti-fungal due to its ability to act as a chitin synthesis inhibitor. Chitin makes up a good portion of the exoskeletons of insects and chitin inhibitors can prevent this exoskeleton from forming. Chitin is also found in the cell wall of candida to varying degrees, depending on the environmental stresses that candida encounters, but under normal conditions, it makes up 0-25% of candida’s cell wall. Unlike the exoskeleton of insects, candida has an ability to manipulate the chitin content in its cell wall membranes. If the environment that it finds itself in has chitin inhibitors, it will alter its chitin content to preserve the integrity of its cell wall membrane. Sites that sell lufenuron would like you to think that candida doesn’t have this ability, which reveals a deep misunderstanding of how candida functions.

Researchers from the University of California, San Francisco, decided to look at whether or not lufenuron had any anti-fungal effects. They found, “No evidence of inhibition, either by susceptibility testing or direct microscopic examination of treated cells, was obtained with lufenuron”. In contrast, they showed that a known chitin synthesis inhibitor, Nikkomycin Z, had a potent inhibitory effect against chitin in fungal cell wall membranes. Their conclusion –  “lufenuron does not appear to possess anti-fungal properties”.

Examining the scientific literature on lufenuron reveals other information that these sites fail to mention:

Lufeneron showed initial promise as a treatment for fungal infections, but the early enthusiasm has dampened considerably as efficacy appears doubtful.

Adverse effects reported in dogs and cats after oral lufenuron include: vomiting, lethargy/depression, pruritus/urticaria, diarrhea, dyspnea, anorexia, and reddened skin. The manufacturer reports that the adverse reaction rate is less than 5 animals in one million doses.http://www.scribd.com/doc/72234998/76/LUFENURON

Of relevance to microbiology, chitin is present in fungal species such as mushrooms, where it can comprise from 5% to 20% of the weight of the organismhttp://www.enotes.com/chitin-reference/chitin

Chitin synthesis inhibitors share a similar chemical structure as other benzoylphenyl ureas.Their mode of action is by interfering with the polymerization pathway of chitin, inducing accumulation of the monomer uridine diphospho-N-acetylglucosamine and blocking its synthesis (Beeman 1982). http://ddr.nal.usda.gov/bitstream/10113/8686/1/IND43666733.pdf

The final step  of  chitin  biosynthesis is  the polymerization of  N-acetylglucosamine from  the  activated  substrate  UDP-N-acetylglucosamine,  by  the  enzyme  chitin  synthase (EC 2.4.1.16).  This enzyme has been well studied in fungi  and yeasts (Gooday 1977)…Leighton e t  al.  (1981)  have  proposed that diflubenzuron  acts indirectly  on  chitin synthase  by inhibiting a  proteolytic enzyme  required for its  activation from  the  zymogen form. http://www.publish.csiro.au/?act=view_file&file_id=BI9820491.pdf

Lufenuron is a benzoylphenylurea drug that interferes with chitin synthesis. It is used in veterinary medicine as a flea prophylactic product, due to its non-specific inhibitory effect on chitin synthesisprobably related to serine protease inhibition.³ http://jfm.sagepub.com/content/11/2/91.full.pdf

OTHER REASONS NOT TO USE CHITIN SYNTHESIS INHIBITORS INCLUDE ITS ABILITY TO AFFECT INTESTINAL MEMBRANES AND FEMALE REPRODUCTION:

An unexpected result of lufenuron treatment was the inhibition of midgut epithelial cell differentiation. At concentrations of 0.5 and 1.0 ppm, partially differentiated epithelial cells were seen in the midgut of blood-fed fleas along with fully differentiated cells. http://www.ncbi.nlm.nih.gov/pubmed/10467778

Micrographs of ovaries, from animals treated with lufenuron, showed some space between the follicular epithelium and the oocyte membrane. The in vivo incorporation of radioactive N-acetylglucosamine into chitin was inhibited by the presence of lufenuron. http://journals2.scholarsportal.info/details.xqy?uri=/00483575/v98i0001/59_te…

LUFENURON BUILDS UP IN THE TISSUES:

Lufenuron bioaccumulateshttp://www.syngenta.co.nz/msds/syngentanz/MATCH_24106015.pdf

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The studies above demonstrate that lufenuron can cause intestinal cell line damage and leaky gut. One benefit of the intestinal cells is that they regenerate quickly, thus demonstrating their ability to heal and restore the intestinal barrier. Lufenuron has the ability to block this regeneration. It’s role in serine protease inhibition could lead to chronic inflammatory conditions, food allergies, autoimmune diseases, etc.
Lufenuron can also interfere with absorption of N-Acetylglucosamine, necessary for the formation of the cell walls in many beneficial bacteria.
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Disturbance of the epithelial barrier and epithelial transport processes is often discussed to be a major factor in the pathogenesis of intestinal inflammation and inflammatory bowel disease. http://www.hindawi.com/journals/iji/2010/574568/

The intestinal epithelium provides a critical protective barrier against enteric pathogens, food antigens, and physiochemical stresses caused by digestive and microbial products, and yet must be selectively permeable to beneficial nutrients and fluids. Tightly regulated control of barrier function and integrity is critical, as the pathogenesis of intestinal diseases such as Crohn’s disease, ulcerative colitis, inflammatory bowel diseases (IBD), and autoimmune diseases are linked to intestinal barrier dysfunction and increased intestinal permeability (1). The intestinal epithelium is a single layer of linked columnar epithelial cells that regulates, through the paracellular pathway, the selective passage of ions, fluid, and macromolecules from the intestinal lumen into the underlying tissues.

The intestinal epithelium serves as a major protective barrier between the mammalian host and the external environment. Here we show that the transmembrane serine protease matriptase plays a pivotol role in the formation and integrity of the intestinal epithelial barrierSt14 hypomorphic mice, which have a 100-fold reduction in intestinal matriptase mRNA levels, display a 35% reduction in intestinal transepithelial electrical resistance (TEER). Matriptase is expressed during intestinal epithelial differentiation and colocalizes with E-cadherin to apical junctionalcomplexes (AJC) in differentiated polarized Caco-2 monolayers. Inhibition of matriptase activity using a specific peptide inhibitor or by knockdown of matriptase by siRNA disrupts the development of TEER in barrier-forming Caco-2 monolayers and increases paracellular permeability to macromolecular FITC-dextran. Loss of matriptase was associated with enhanced expression and incorporation of the permeability-associated, “leaky” tight junction protein claudin-2 at intercellular junctions.  These results support a key role for matriptase in regulating intestinal epithelial barrier competence, and suggest an intriguing link between pericellular serine protease activity and tight junction assembly in polarized epithelia. http://www.pnas.org/content/107/9/4200.full

“Mechanisms terminating the short physiological life cycle of epithelial cells are supposed to have an impact on these essential functions and have influence on inflammatory reactions in the intestinal mucosa. A disturbance of the epithelial barrier is thought to be a major factor in the pathogenesis of inflammatory bowel disease.

Disturbance of the epithelial barrier and epithelial transport processes is often discussed to be a major factor in the pathogenesis of intestinal inflammation and inflammatory bowel disease.”

http://www.hindawi.com/journals/iji/2010/574568/

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One website that sells lufenuron has pictures of inflammatory skin conditions that responded to lufenuron treatment. A deficiency of serine protease inhibitors can play a role in creating inflammatory skin conditions. The website implies that the healing seen in the pictures was created by lufenuron’s anti-fungal affect against candida. It is much more likely that this was due to its serine protease inhibition effect. I’ve talked frequently about how people misinterpret what they see and notice. This would be a classic example.

Lufenuron has demonstrated the ability to damage intestinal cells and intestinal cell junctions. As noted above, intestinal cells play a critical role in the maintenance of the homeostasis of the intestinal tract. Lufenuron can also interfere with the structure of healthy intestinal bacteria. It had initially demonstrated a possible role in affecting candida fungal growth that subsequent studies dismissed. The goal of any approach in restoring balance to the intestinal flora, immune responses, and candida overgrowth, should not also present known risks to the body. Based on this, I would never recommend lufenuron.

A while back, someone consulted with me about doing the Candida Plan and taking a product called lufenuron at the same time. I told him that I wouldn’t recommend using an insecticide designed for animals, in humans. It seemed like there could be some unknown risk associated with it. He assured me that after talking with a distributor of the product that he would be okay and that there was no harm in its use. I wished him well, as he has been dealing with his health issues for some time.
Three weeks later, he emailed me that he now had leaky gut, which matched a possible effect of research associated with the use of serine protease inhibitors. Another woman emailed me about gobs of mucus that she was coughing up all day long -“Shortly after completing a Clare Davidson’s candida cleanse 45-day treatment, I developed a strange symptom – my saliva started to thicken and bubble. It’s now quite viscous, rubbery I’d say.” By interfering with the action of enzymes in her body, she was now unable to thin out the mucus secretions that her body was producing.
Approaches that don’t take into consideration the whole body, but address candida as though it exists in an isolated sphere or on a petri dish somewhere, are bound to fail, have short-lived results, or even cause harm. Lufenuron achieves all three of these results.
Correcting fungal candida imbalances requires safely correcting the fungal form of candida back to its normal yeast form, boosting the appropriate immune response, detoxifying the body, and helping to restore healthy bacterial flora. This is the whole-istic approach.
Get started on a healthier life today with Dr. McCombs Candida Plan.
Jeff McCombs

  • guest

    scaremongering and not true fact….clearly just trying to sell a more expensive plan….how does the writer explain the clinical trial on CCWS website?
    Has CCWS™ been tested on humans?

    In the winter of 2014, a double-blind clinical study has been conducted with 200 subjects and 50 placebo. Based on the saliva and blood tests completed after taking CCWS™, 80% of the subject experienced a 99.9% relief. The remaining 20% experienced at least a 50% relief. An average weight loss of 11 pounds from day 1 to day 45 was measured in these subjects. *Subjects did not have a change to their diets nor did they have changes to their exercise routines.

    The remaining 20% subjects that did not have at least a 98% removal of Candidasis based on saliva and blood test were placed into a follow-up study directly following the first protocol. After taking another course of the CCWS™, 100% of the subjects experienced approximately 99.9% relief from Candidasis.

    100% of subjects stated they felt better on day 45 than they did on day 1 using CCWS™.

    100% of the placebos experienced a 0.0% relief from Candidasis from the placebo product based on saliva and blood tests.

    • GUEST

      well said!
      the PTB have gotten to "natural news".
      PEOPLE! educate yourself and do not be spoon fed this propaganda!
      why is lufenuron an effective treatment for candida and parasites in animals but not humans?
      see sense!
      those studies quoted in this article all have their funding from drug companies.
      follow the money:
      ask yourself questions: do the PTB want people to be healthy? do the PTB want people to have a healthy mind
      to think for themselves?
      who benefits from you being sick with candida?
      if lufenuron is a perfectly safe and effective treatment for animals, available otc w/o a prescription, how does that translate to a dangerous product for humans?
      it DOESN'T.

  • Rosie

    So, does CWWS contain Lufenuron or Nikkomycin Z?

  • tools4retooling

    I read almost all of the info on the CCWS…I was totally shocked at the price, so I decided to do a search. I very much trust the Natural News info and Mike Adams. I am bewildered…battling systemic fungal infection ever since late 2006!

    • Kristen

      If you have been battling Systemic Candid for 9 years you should definitely try CCWS!

  • Kristen

    There are some things that do not make sense in this article. Especially the bit at the end where the writer says his friend developed a Leaky Gut AFTER the Clare Davidson Candida Cleanse. If his friend already had Systemic Candida then he ALREADY had Leaky Gut prior to starting the cleanse!! DUH!! Leaky Gut is what causes Systemic Candida in the first place! I tried the Clare Davidson Candida Cleanse and it worked amazing at clearing up the chronic eczema I suffered with for years. Yes it is expensive but highly worth it! I wasted TONS of money on supplements that helped very little. By the way have you checked out the price of Dr. McCombs Candida Plan? It's $604.00!! I researched the products he is selling and it's all stuff that you can buy at the health food store for a quarter of that price! It's not that hard to figure out if you do your research. 1) Do not eat sugar or other refined carbs that feed candida. 2) Heal your leaky gut with L-Glutamine 3) ensure you are getting 40-60 grams of fibre to eliminate toxins from the colon 4) Take Probiotics at least 100 million worth!!

  • Candice

    Cellulase fixed the issue for me.